Patients at highest risk of drug induced nephrotoxicity are those with one or more of the following. Dioscin adjusted fxrmediated signal pathway in vitro and vivo. Effect of pcoumaric acid on apoptosis in doxorubicininduced nephrotoxicity in rats. Doxorubicin 10mgkg body weight was administered twice and. The suitability of dox is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. Effect of pentoxifylline against doxorubicininduced nephrotoxicity. Cardiotoxicity is the chief toxic effect that limits the clinical use of dox. Drug induced nephrotoxicity is caused by nephrotoxic drugs or toxins which damage kidneys and can lead to nephritis or renal toxicity. Doxorubicininduced in vivo nephrotoxicity involves oxidative.
Hibiscus sabdariffa extract alleviate nephrotoxicity. Nephrotoxicity is one of the limiting factors for using doxorubicin dox as an anticancer chemotherapeutic. Dioscin significantly suppressed oxidative stress and inflammation. B 51 and caspase3 52 were increased significantly in doxorubicin induced nephrotoxicity. Osiagwu4 1department of pharmacology, therapeutics and toxicology, faculty of basic medical sciences, college of medicine, university of. Alleviation of doxorubicin induced nephrotoxicity by clerodendrum volubile leaf extract in wistar rats. In addition, our findings suggest that dox induced nephrotoxicity may play a role in dox induced cardiac dysfunction in rodent models.
Interleukin 1 has major role in dox induced nephrotoxicity, so we investigated the effect of interleukin 1 receptor antagonist diacerein dia on dox induced nephrotoxicity. Herein, we have investigated the potential protective effect of irbesartan irb against chronic nephrotoxicity induced by dox, and the implication of different. Mar 16, 2017 doxorubicin is a highly effective anticancer agent but causes cardiotoxicity in many patients. A single dose of doxorubicin 15 mg kg which caused nephrotoxicity was manifested biochemically by the elevation of serum urea after 24 and. Protective effect of irbesartan against doxorubicininduced. Alleviation of doxorubicininduced nephrotoxicity and. Protection from doxorubicininduced nephrotoxicity by. A novel hybrid cytokine il233 mediates regeneration. Pdf alleviation of doxorubicininduced nephrotoxicity and. Doxorubicin 75 and ifosfamide therapy indications for use. Hibiscus sabdariffa extract alleviate nephrotoxicity induced. Doxorubicin dox is an important anticancer drug used widely in the treatment of leukemia and lymphoma. Doxorubicin dox, a wellknown chemotherapeutic drug, has been reported to induce numerous toxic side effects including renal toxicity. Thyme oil and thymol abrogate doxorubicin induced nephrotoxicity and cardiotoxicity in wistar rats via repression of oxidative stress and enhancement of antioxidant defense mechanisms osama m.
Quercetin attenuating doxorubicin induced hepatic, cardiac and renal toxicity in male albino wistar rats. Nephrotoxicity is one of the limiting factors for using doxorubicin dox. Sexual dimorphism of acute doxorubicininduced nephrotoxicity. Doxorubicin, nephrotoxicity, pentoxifylline, rabbits. We aimed to investigate blap protective potential against doxorubicin doxinduced nephrotoxicity in mice. Oct 17, 2012 doxorubicin, a very potent and often used anticancer drug, is largely limited due to the doserelated toxic effects. Protective effects of madecassoside against doxorubicin. Yiqi fumai lyophilized injection attenuates doxorubicin. Doxorubicin, cardiotoxicity, sexual dimorphism background the survival rate of. Dec 18, 2019 this study was performed to examine whether clindamycin could protect against doxorubicin dox induced acute nephrotoxicity, and if so, what molecular mechanisms responsible for this protective effect. A61k 3600 introduction nephrotoxicity is one of the important side effects of anthracycline antibiotics.
Cisplatininduced renal toxicity has been related to a perturbation of intracellular ca. Alleviation of doxorubicininduced nephrotoxicity by clerodendrum. Possible protective effect of diacerein on doxorubicin. Drug induced nephrotoxicity is caused by nephrotoxic drugs that cause kidney damage. The aim of this study was to investigate the effects of nicotinamide nad, an antioxidant agent, against nephrotoxicity induced by doxorubicin dxr. Dioscin shows active effects against renal ischemiareperfusion injury and lipopolysaccharide induced inflammatory kidney injury, however, little is known concerning the role of it on doxorubicin dox induced nephrotoxicity. Phytomodulatory potential of lycopene from lycopersicum. Protective effects of dioscin against doxorubicininduced. The aim of the study was to determine the protective effect of solanum torvum on doxorubicininduced nephrotoxicity in rats using biochemical and histopathological. Protective effect of carvedilol alone and coadministered with. Doxorubicin induces cardiotoxicity through upregulation of. Aliskiren alleviates doxorubicininduced nephrotoxicity by. Lahoti, darshan patel, venkatesh thekkemadom, robert beckett and sidhartha d. Moreover, the effect of qur in the presence of dox on the cell viability of four different.
Yiqi fumai lyophilized injection attenuates doxorubicininduced cardiotoxicity, hepatotoxicity and nephrotoxicity in rats by inhibition of oxidative stress, inflammation and apoptosis yue gu, a aichun ju, b bingjie jiang, a jingze zhang, c shuli man, d changxiao liu e and wenyuan gao a. Effect of two doses of coenzyme q10 coq10 on renal caspase 3 immunohistochemical semiquantitative analysis in rats exposed to doxorubicin dox induced nephrotoxicity. Effect of coenzymeq10 on doxorubicininduced nephrotoxicity in rats. The anthracycline antitumor drug doxorubicine causes severe nephrotoxicity in a variety of experimental animals and may be nephrotoxic to humans.
Lahoti, darshan patel, venkatesh thekkemadom, robert beckett, sidhartha d. Doxorubicininduced in vivo nephrotoxicity involves. Artemisinin can protect the kidney and testis against doxorubicininduced nephrotoxicity and testotoxicity, probably through a decrease of caspase3, tnf. Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Prevention of doxorubicininduced renal toxicity by theanine in rats. This however, the optimal clinical use of dxr has been cur. Quercetin attenuating doxorubicin induced hepatic, cardiac. Female rodents have been shown to be protected against several features of dox induced nephrotoxicity. The aim of the study was to determine the protective effect of solanum torvum on doxorubicin induced nephrotoxicity in rats using biochemical and histopathological. Kidneys were isolated from control untreated group, animals treated with low or high dose coq10 coq10l or coq10h, resp. The resultant homogenates were then centrifuged at 3000 rpm for 15 min, and the supernatants were aspirated and frozen at 30oc, until. Doxorubicin dox is a chemotherapeutic agent that has been reported to cause.
Protective effects of berberine on doxorubicininduced. Effect of pcoumaric acid on apoptosis in doxorubicin induced nephrotoxicity in rats. Effects of quercetin on kidney injury induced by doxorubicin. At the end of the 10th day, kidney tissues were removed for light. By continuing to use our website, you are agreeing to our use of cookies. In the present study, we investigated the protective efficacy of chrysin against dxr induced oxidative stress, nephro and hepatotoxicity in male wistar rats using.
Trpc3nox2 complex mediates doxorubicininduced myocardial. Several studies have reported that expressions of inos 10, 49, tnf. Doxorubicininduced in vivo nephrotoxicity involves oxidative stress mediated multiple pro and antiapoptotic signaling pathways. Thyme oil was subjected to gcms analysis, which indicated that thymol was the major constituent representing 33. Doxorubicin, lycopene, nephrotoxicity, phytomodulation doxorubicin dox is an anthracycline chemotherapeutic drug commonly used for the treatment of a wide variety of cancers1. Doxorubicin, nephrotoxicity, pentoxifylline, rabbits introduction oxorubicin dox is an anthracycline antineoplastic drug1. Pdf protective effect of solanum torvum on doxorubicin. Doxorubicin induced in vivo nephrotoxicity involves oxidative stress mediated multiple pro and antiapoptotic signaling pathways volume. Antitumor activity, cardiotoxicity, and nephrotoxicity induced by doxorubicin were studied in loumwsl inbred rats each bearing a transplantable sol we use cookies to enhance your experience on our website. A arrowheads indicate apoptotic cells stained positive in the tunel assay.
However, optimal use of dox is limited by a number of side. Antioxidant, doxorubicin, nephrotoxicity, psidium guajava ipc code. In the present study, in vivo test of dox induced nephrotoxicity in rats and in vitro model in nrk52e cells were developed. Nephrotoxicity is one of the serious undesirable effects related to doxorubicin dox. A novel hybrid cytokine il233 mediates regeneration following. Jun 16, 2011 nephrotoxicity is one of the important side effects of anthracycline antibiotics. Animal studies have shown activity in a spectrum of experimental tumors, immunosuppression, carcinogenic properties in rodents.
Rats intraperitoneally injected with dox at a dose of 2 mgkg b. Therefore, male sprague dawley rats were divided into eight groups, control group, ellagic acid 10mgkg, p. Research article dalbergioidin ameliorates doxorubicin. Research article possible protective effect of diacerein on doxorubicininduced nephrotoxicity in rats marwam. These drugs need to be identified and avoided to prevent kidney injury. Doxorubicin induced apoptosis may be an integral component of the cellular mechanism of action relating to therapeutic effects, toxicities, or both. Protective effect of irbesartan against doxorubicin induced nephrotoxicity in rats. This study investigated the effects of different doses of qur on doxorubicin dox. However, its clinical use is limited because of several side effects like cardiotoxicity, nephrotoxicity and hepatotoxicity.
Doxorubicin dxr, an anthracycline antibiotic and is used for the treatment of a variety of neoplastic conditions including leukemias, lymphomas and solid tumors. Pcoumaric acid mitigates doxorubicininduced nephrotoxicity. Comparison of nephrotoxicity of pirarubicin and doxorubicin. The present study investigated whether berberine, a natural product alkaloid, can reduce the renal injury induced by doxorubicin. Thymoquinone attenuates doxorubicin induced nephrotoxicity in rats. Department of pharmaceutical sciences manchester university college of pharmacy 10627 diebold rd, fort wayne, in 46845, usa. The interplay between genetic background and sexual. The present study aimed to assess the protective effect of proanthocyanidins pas against dox. Effect of coenzymeq10 on doxorubicininduced nephrotoxicity. Alleviation of doxorubicininduced nephrotoxicity by. Hypoalbuminemia and hypercholesterolemia appeared after the doxorubicin injection. These results suggest that theanine prevents doxinduced acute nephrotoxicity through its antioxidant properties. We studied the effects of tetrandrine tet on doxorubicininduced cardiotoxicity in rats and its protective activity.
Sexual dimorphism of acute doxorubicininduced nephrotoxicity in. Male albino rats were pretreated with clindamycin once per day for 5 consecutive days at a dose of 300 mgkg, i. Trpc3nox2 complex mediates doxorubicin induced myocardial atrophy tsukasa shimauchi, 1,2,3 takuro numagatomita, 1,4 tomoya ito, 1 akiyuki nishimura, 1,4 ryosuke matsukane, 1,2 sayaka oda, 1,4 sumio hoka, 3 tomomi ide, 5 norimichi koitabashi, 6 koji uchida, 7 hideki sumimoto, 8 yasuo mori, 9 and motohiro nishida 1,2,4,10. Key words nephroprotection doxorubicin captopril olmesartan melatonin c21 substance oxidative stress corresponding author fedor simko, department of pathophysiology, school of medicine, comenius university, sasinkova 4, 811 08 bratislava, slovak republic. Nephrotoxicity is one of the important side effects of anthracycline antibiotics. Lapachone blap is a natural naphtaquinone with established antioxidative stress and anticancer activities. International journal of molecular sciences article the ef. Abdelrahman 1 department of pharmacology, faculty of medicine, elminia university, elminia, egypt. Effect of coenzymeq10 on doxorubicininduced nephrotoxicity in rats article pdf available in advances in pharmacological sciences 20124. Acute doxinduced nephrotoxicity was induced by a single intraperitoneal injection of 20 mgkg. Pdf means of evaluation and protection from doxorubicin. Key words nephroprotection doxorubicin captopril olmesartan melatonin c21 substance oxidative stress corresponding author fedor simko, department of pathophysiology, school of medicine.
The ameliorative effect of ellagic acid and rosemarinic acid. The rats were divided into control, nad alone, doxorubicin 20 mgkg, i. Antitumor effect, cardiotoxicity, and nephrotoxicity of. The aim of present study was to determine the protective effects of quercetin against doxorubicin induced kidney injury with light microscopy. The aim of the study was to investigate protective effects of curcumin cmn against dxr induced nephrotoxicity. Research article doxorubicin induced nephrotoxicity. Zaky department of pharmacology and toxicology, faculty of pharmacy girls, alazhar university, cairo, egypt. Doxorubicin dox is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. The ameliorative effect of ellagic acid and rosemarinic.
Protective effect of carvedilol alone and coadministered. This study was performed to examine whether clindamycin could protect against doxorubicin dox induced acute nephrotoxicity, and if so, what molecular mechanisms responsible for this protective effect. Introduction doxorubicin dxr is an anthracycline glycoside antibiotic that has broadspectrum antitumor activity against a variety of human solid tumors such as ovarian, breast, and lung cancers as well as several other cancers and hematologic malignancies. However, nephrotoxicity reduces its clinical utility in humans. Research article possible protective effect of diacerein. Protective effect of proanthocyanidins against doxorubicin. Effect of coenzymeq10 on doxorubicin induced nephrotoxicity in rats.
Doxorubicin dxr is one of the most important chemotherapeutic agent. The mechanisms of doxorubicin induced cardiotoxicity remain incompletely understood. Chemoprotective effects of curcumin on doxorubicininduced. Doxorubicin dox exerts toxic effects in several organs particularly kidney. Protective effect of captopril, olmesartan, melatonin and. The causative drug must be identified and its use must be. During or immediately after administration, adequate amounts of fluid should be. This preliminary study was designed to investigate the ameliorative effects of methanolic leaf extract of clerodendrum volubile mecv against dox induced nephrotoxicity in rats. This may occur for 12 days after administration of doxorubicin. Thyme oil and thymol abrogate doxorubicin induced nephrotoxicity and cardiotoxicity 43 homogenized in isotonic saline 0.
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