Research square is the platform powering protocol exchange. Pdf stimulustriggered fate conversion of somatic cells. Included in the issue are words of advice for students from journal keeping smithsonian naturalists. Obokata fails to reproduce stap cell discovery the japan. Here we report a unique cellular reprogramming phenomenon, called stimulustriggered acquisition of pluripotency stap, which requires neither nuclear transfer nor the introduction of transcription factors. The oral mucosa is an attractive cell source for autologous transplantation in human patients who require regenerative therapies of various epithelia. Investigation of the cellular reprogramming phenomenon. Sep 11, 2014 the science news team received a copy of email correspondence between a nature editor and haruko obokata, the lead author of the papers, that indicates the work initially received as rocky a. Stimulustriggered acquisition of pluripotency wikipedia. Stimulustriggered acquisition of pluripotency also known as stap was a proposed method of generating pluripotent stem cells by subjecting ordinary cells to certain types of stress, such as the application of a bacterial toxin, submersion in a weak acid, or physical trauma.
Jan 29, 2014 now two manuscripts by haruko obokata and colleagues describe an unexpected reprogramming phenomenon, which the authors call stimulustriggered acquisition of pluripotency stap. Jul 02, 2014 in view of the fact that the authors of stimulustriggered fate conversion of somatic cells into pluripotency h. Jul 02, 2014 the scientific journal nature wednesday retracted two stem cell papers that received national attention when they were published in january the paper by researchers from harvard university and. Nevertheless, it is a serious problem that the collaborators and coauthors overlooked this point. Nature journal retracts gamechanger stemcell study update 2 july 2014 leading science journal nature is withdrawing a stemcell study published in january that had been hailed as a. European journal of crime, criminal law and criminal justice, 16, 265282 article. The term nature journal seems to resist definition until we realize that the broadest definitions all apply. The saved searches option allows a registered user to view the previous searches saved by a user. Obokatas suspicions over her onetime mentor teruhiko wakayama, a coauthor of the nature papers and a former riken researcher who. We read with enthusiasm the recent opinion article by jigisha patel in bmc medicine. Nature journal retracts gamechanger stemcell study. Haruko obokata of rikagakukenkyusho riken received the spotlight suddenly with the discovery of the new pluripotency cells. In january 2014, a letter and original research article were published in nature describing a process whereby somatic mouse cells could be converted into stem cells by subjecting them to stress. Takao obokata department of biomaterial sciences, graduate school of agricultural and life sciences, university of tokyo, yayoi 11.
Maybe a favourite spot in your garden, or a park bench. Trendsetting women scientists of biomedical research in japan. May 28, 2014 japanese news media are reporting that haruko obokata and other key authors have agreed to retract the nature stap cell letter, but not the nature article. Researcher of the coveted pluripotency stap cells, ms. Obokata became a guest researcher at the riken center for developmental biology in 2011, and she was appointed as head of the lab for cellular reprogramming in 20. Haruko obokata lead author, corresponding author, yoshiki sasai corresponding. Now two manuscripts by haruko obokata and colleagues describe an unexpected reprogramming phenomenon, which the authors call.
Nature post nature a paper in new formations 26 spring 2008 5164. In 2014, she published two papers in the journal nature. Response by obokata and borlaug to letters regarding. The science news team received a copy of email correspondence between a nature editor and haruko obokata, the lead author of the papers, that indicates the work initially received as.
Just this year, on january 30, 2014 the scientific journal naturepublished 2 papers by haruko obokata et al. In view of the fact that the authors of stimulustriggered fate conversion of somatic cells into pluripotency h. Japan lab says stem cell research falsified update 3 1 april 2014, by elaine kurtenbach. Obokata fails to reproduce stap cell discovery the.
Obokata, author of retracted stemcell papers, tells her side. Now two manuscripts by haruko obokata and colleagues describe an unexpected reprogramming phenomenon, which the authors call stimulustriggered acquisition of. Browse the latest research, submit a preprint, or purchase. Aug 03, 2015 obokata reported finding a simple and easy new method to produce many stem cells with 2 papers in the stellar science journal, nature. Jan 29, 2014 the work, reported in two papers in the journal nature, was a major scientific discovery that will be opening a new era in stemcell biology, said dusko ilic, a stemcell scientist at kings. Patrick curry my goal here is to outline a plausible and progressive way to think about nature which takes seriously both nonessentialism, latterly postmodern, and ecocentrism. Browse the latest research, submit a preprint, or purchase author services, such as editing, formatting and custom videos. Obokatas guardian spirit revealed her true thoughts recorded april 8, 2014 ms. Apr 22, 2015 nature collection nature journal april 22, 2015 by barb mccoy leave a comment this month there are two things i am aiming to include in my nature journal. Sep 24, 2015 pdf on sep 24, 2015, daijiro konno and others published stap cells are derived from es cells find, read and cite all the research you need on researchgate.
Mar, 2018 in the obokata case, nature managed to export its intent to selfcorrect into a number of news reports. In our opinion, to take down retracted papers from journal websites amounts to an attempt to rewrite history, and. Obokata was the first author of both articles, whose results would apply in several areas, including regenerative medicine. Stimulustriggered fate conversion of somatic cells into pluripotency, nature on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Japan lab says stem cell research falsified update 3. Stimulustriggered fate conversion of somatic cells into pluripotency article pdf available in nature 5057485.
Stimulustriggered fate conversion of somatic cells. Therefore, acquisition of pluripotency by somatic cells via reprograming is typically assessed based on such criteria. Dec, 2007 the oral mucosa is an attractive cell source for autologous transplantation in human patients who require regenerative therapies of various epithelia. A simple and rapid system for dna and rna isolation from diverse plants using handmade kit. Since ugcinfonet has got subscription for only the nature journal, users will select nature only from select journals from a list. Coauthor of controversial acid stap stem cell papers in nature. Summary report on stap cell research paper investigation ii. Japan news scientists struggle to replicate stemcell. Nature journal retracts stap papers, citing critical errors the. In particular, wakayama who headed the laboratory in which obokata worked, and sasai, who played a major role in compiling the final version of the stap cell papers, both bear heavy responsibility. Obokata reported finding a simple and easy new method to produce many stem cells with 2 papers in the stellar science journal, nature.
Now two manuscripts by haruko obokata and colleagues describe an unexpected reprogramming phenomenon, which the authors call stimulustriggered acquisition of pluripotency stap. Stimulustriggered fate conversion of somatic cells into pluripotency. Results of an attempt to reproduce the stap phenomenon ncbi. Scientists struggle to replicate stemcell research breakthrough new approach called into question updated feb. The work, reported in two papers in the journal nature, was a major scientific discovery that will be opening a new era in stemcell biology, said dusko ilic, a stemcell scientist at kings. In the spring of 2012, vacanti, obokata, and wakayama made their first submission to nature. In two reports published in nature by obokata et al. The results reported by obokatas team in producing pluripotent stem cells from somatic cells by a convenient and simple low. The torrent of questions about the quality of the first paper brought the. Jun, 2014 two papers that electrifiedand confusedthe stem cell field just 6 months ago appear to have lost their last defenders. Stem cell scandal scientist haruko obokata resigns, bbc news, december 19, 2014 33. I should know better than to expect sit down work from my boys when we are out in unlandscaped wild nature.
However, the image data and research data received criticism and she has been thrust into controversy. Review of obokata stress reprogramming nature papers the. Stimulustriggered fate conversion of somatic cells into. The journal nature said the papers which detailed an easy way to create stem cells were errorfilled and had not been verified by anyone else. Nature journal retracts gamechanger stemcell study update. Pdf on sep 24, 2015, daijiro konno and others published stap cells are derived from es cells find, read and cite all the research you need on researchgate. No one shall be deprived of his possessions except in the public interest and subject to the conditions provided for by law and by the general principles of international law. The journal rejected their manuscript, arguing that they had failed to prove that the cells had.
Obokata and her team were lauded after their papers on the purported stap discovery appeared in the prestigious journal nature earlier this year. The journals article metrics allow for some understanding of the impact these articles have attracted so far, before their inevitable retraction at the time of. Obokata, author of retracted stemcell papers, tells her. Included in the issue are words of advice for students from journalkeeping smithsonian naturalists.
We thank drs koutsampasopoulos, jinshan, carbone, and colleagues for their interest in our recent publication characterizing cardiovascular structure, function, and reserve capacity in patients with the obese phenotype of heart failure with preserved ejection fraction hfpef. Haruko obokata, teruhiko wakayama, yoshiki sasai, koji kojima, martin p. A subheadline in the wall street journal, for example, proclaimed. The results of the study1 were published in the journal nature in 2014. Browse by subject a user can browse the journal by subject or by the specific journal issue. They would rather explore, hike, forage, and make fire than sit. Nature collection nature journal april 22, 2015 by barb mccoy leave a comment this month there are two things i am aiming to include in my nature journal.
Trendsetting women scientists of biomedical research in. Nature postnature a paper in new formations 26 spring 2008 5164. Et scientists say they are struggling to replicate a new approach for creating stem cells, raising further questions about the breakthrough technique whose announcement garnered international attention. In the obokata case, nature managed to export its intent to selfcorrect into a number of news reports. This is just a location to return to again and again to observe and record nature. Review of obokata stress reprogramming nature papers the niche. Scientificpublic interface in times of correction of scientific literature. At first obokata staunchly defended her work in the face of serious doubt and criticism, but last month she agreed to retract the papers. The results reported by obokata s team in producing pluripotent stem cells from somatic cells by a convenient and simple low. The result of doing so i call ecopluralism, and i hope it might help to bring about a more. Stem cell research papers are retracted the new york times. In two nature papers here and here published today researchers report the astounding finding of reprogramming. Last week, lead author haruko obokata of the riken center for developmental biology cdb in kobe, japan, agreed to retract a nature paper that described a startlingly easy way to produce stem cells. Science journal retracts paper on stem cell discovery.
Both of these backgrounds were used in the retracted nature papers. The scientific journal nature wednesday retracted two stem cell papers that received national attention when they were published in january. Subcutaneous transplantation of autologous oral mucosal. Edextended data figurestimulustriggered fate conversion of som.
Nature computational science will be published onlineonly, and for submissions from january 2021, the journal will be a transformative journal, meaning that plan sfunded authors, as well as others wishing to publish open access, can submit their primary research to these journals safe in the knowledge that they will be complying with their. Japanese news media are reporting that haruko obokata and other key authors have agreed to retract the nature stap cell letter, but not the nature article. The value of international law in combating transnational. Obokata s suspicions over her onetime mentor teruhiko wakayama, a coauthor of the nature papers and a former riken researcher who.
1510 1175 446 278 1550 1066 115 1378 304 720 458 1248 579 511 387 512 192 1519 712 495 1347 548 786 1271 810 367 116 1316 1317 527 7